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KMID : 0367420040470080904
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Journal of Korean Pediatric Society
2004 Volume.47 No. 8 p.904 ~ p.907
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A Case of Kikuchi-Fujimoto Disease, Subsequently Evolving to Systemic Lupus Eyrthematosus.
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Yoon Soon-Hwa
Song Myoung-Hoon
Shin Seon-Hee
Kim Sung-Koo
Lee Kon-Hee
Yoon Hae-Sun
Jung Young-Ok
Ahn Hye-Kyung
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Abstract
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Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is a self-limited systemic illness and it has the pathognomonic histological appearance of lymph nodes. KFD is rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Our case describes a young woman, originally diagnosed as having Kikuchi’s disease by lymph node histology, who subsequently developed SLE with constitutional symptoms, skin rash, hematologic and immunologic disorder and high titer of antinuclear antibody. This raises consideration for the proposal that KFD may reflect a SLE-like auto-immune condition. Patients with KFD should be kept under observation for several years for the development of SLE. And KFD should be ruled out in SLE flare-up accompanied by lymphadenopathy. (Korean J Pediatr 2004;47:904-907)
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KEYWORD
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Kikuchi-Fujimoto disease, Histiocytic necrotizing lymphadenitis, Systemic lupus erythematosus
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